Great Danes are affectionate giants who combine larger size with a friendly personality. Their popularity as pets has resulted in many Great Dane mixes, each with unique traits from their parent breeds.
This purebred Great Dane cannot be ignored because of its size and elegance. An adult male can reach up to 34 inches tall at the shoulder and weigh more than 200 pounds.
However, the largest dogs are usually gentle giants and are friendly with people they know well, even though they might look scary to strangers. This makes them perfect companions for families or individuals.
Although they were initially bred in Germany to hunt wild boars, most now want nothing more than to be loved by their owners and show this through cuddles all day.
They have a calm temperament and a dignified presence that has won over many dog lovers’ hearts forever!
This article examines popular Great Dane mixes with other dog breeds, discussing their appearance, common health problems, and temperaments.
1. The American Bulldog x Great Dane Mix
The American Bull Dane is a cross between an American Bulldog and a Great Dane.
It can vary from a medium-sized dog to a large-sized one, weighing from 40 to 190 pounds.
These brave and attentive dogs make them excellent guard dogs, but they also love playing around.
Due to their Bulldog ancestry, some respiratory issues might affect them, so it’s important not to overexert them physically.
2. The Boxer x Great Dane Mix
Also known as the Boxane, this breed is loyal and energetic like any other Boxer dog; however, its calmness comes from the Great Dane side of its lineage.
Boxane dogs usually have well-muscled bodies that weigh between 60 and 150 pounds.
Their playful nature makes them perfect for families, but they need lots of exercise, too!
Boxans may suffer from hip dysplasia and heart problems, which are common in both parent breeds.
3. The Labrador x Great Dane Mix
The Great Labradane combines the friendliness of a Labrador Retriever with the gentleness of a Great Dane, thus making it an excellent family pet.
This Labrador Great Dane mix weighs between 100 and 180 lbs and is generally good with children and other animals.
Joint issues and bloat, which are more likely to occur among these large breeds due to their size, should be monitored closely.
4. The German Shephard x Great Dane Mix
The German Shepherd Great Dane mix, called “the Great Shepherd,” has inherited intelligence from both parents, making them quick learners and protective like German Shepherds.
Great Shepherds are large dogs weighing from 65 to 175 pounds, so they need space to move freely.
They are very loyal and can be trained for multiple tasks, such as herding or acting as guard dogs; however, some may suffer from hip dysplasia and heart conditions, which are common in this breed.
5. The Poodle x Great Dane Mix
The Poodle Great Dane mix, also known as “the Great Danoodle,” combines brains and gentle nature.
These dogs usually grow to be giant in size, ranging between 80-110 lbs; however, they do not shed much hair.
They love being around people, so it’s no surprise that these sociable creatures also get along well with families.
If you decide to get one, watch for bloat or hip dysplasia-related problems, as these can affect larger breeds like this.
6. The Great Dane x Rottweiler Mix
A Rottweiler mix with a Great Dane produces offspring called “the Weiler Dane,” which is strong and sturdy thanks to the muscle power inherited from its parents.
They make good protectors and are loyal to their owners. They also have an imposing size, averaging about 80-190 pounds.
Firm training and quite a bit of exercise are needed for them, so be ready.
When looking at their health issues, joint problems might arise alongside heart diseases, which could be fatal, especially considering how big these dogs can grow up to become!
7. The Great Dane x Saint Bernard Mix
This mix, referred to as “Saint Dane,” happens when gentleness meets more peace-loving qualities – resulting in calm giants in the dogs’ world!
The Saint Danes weigh between 120 and 190 lbs, meaning they are enormous.
However, the breed’s tranquility often extends to other animals, making them excellent companions even within multi-pet households.
Unfortunately, bloat and hip dysplasia are quite common in this mix breed, thanks to their size.
8. The Dalmatian x Great Dane Mix
The Great Dalmatian is a blend of two energetic and gentle breeds in their own right.
Their bodies usually fall into medium or large sizes ranging between 60 to 170 lbs, thus requiring plenty of exercises to stay fit.
However, deafness can be an issue among these dogs because both parent breeds sometimes suffer from it, as well as hip dysplasia, so regular checkups should not be neglected.
9. The Great Dane x Husky Mix
Great Danesky is an energetic breed that combines a Husky’s stamina with a Great Dane’s calmness.
The Husky Great Dane mix is big, weighing between 85 and 190 pounds, and requires plenty of exercise and mental stimulation.
Joint problems and bloat are common health issues that can pop up in this crossbreed.
10. The Mastiff Mix x Great Dane Mix
Daniff is a huge crossbreed between Mastiffs and Great Danes, usually weighing 115 to 230 pounds.
Despite their size, they are gentle giants. These dogs are beautiful additions to any family and get along well with children.
Daniffs need a lot of space to exist, and they have quite high exercise requirements.
Hip dysplasia, bloat, and heart problems can be health concerns in this crossbreed.
11. The Great Dane x Golden Retriever Mix
Great Golden Danes are friendly and affectionate, combining the playful traits of Golden Retrievers with the calm personality of Great Danes.
They generally weigh about 75 to 200 pounds, which is a good size for children to play with!
However, experts say some potential health issues could include hip dysplasia or bloat.
12. The Great Dane x Border Collie Mix
The Great Collie is a combination of Border Collies’ size, intelligence, and agility, combined with the gentleness typical of Great Danes.
They need mental stimulation regularly because they are very active and intelligent dogs, so always keep them busy! If not properly exercised and mentally stimulated, they can easily become destructive.
Weighing between 50 and 150 lbs., this breed may frequently suffer from hip dysplasia and bloat.
13. The Great Dane x Doberman Mix
The Doberman Great Dane mix or Doberdane has loyalty and protective instincts, which make it stand out among other mixed breeds.
A Doberman Pincher’s alertness and gentle disposition, common among most Great Danes, create a dog with an imposing appearance and a heart of gold.
Experts say such dogs should generally weigh from about 85 to 200 lbs.
Heart disease may easily affect these canines if not checked early enough; hence, it is very important to have regular checkups at the vet.
If you are lucky enough to end up with this Dobie mix, you can check out this helpful article about Doberman head shaking and when to react.
14. The Great Dane x Catahoula Mix
This is an energetic dog that combines the herding instincts of Catahoula with the size of Great Danes.
The Catahoula Dane can weigh between 65 and 180 pounds and requires plenty of exercise daily, primarily because of its high energy levels!
In terms of health issues, hip dysplasia or bloat may be common among them, according to veterinary experts.
15. The Great Dane x Newfoundland Mix
Newfie Danes are known as gentle giants. They inherit Newfies’ love for water and the calmness that characterizes all Great Danes.
These canines weigh between 100 and 200 pounds, so it’s no wonder people describe them as giants! They usually fit in with any type of family and do quite well with young children.
However, these dogs may suffer from hip dysplasia and bloat often.
16. The Irish Wolfhound x Great Dane Mix
The Wolfdane is a regal, calm breed that combines the hunting instincts of an Irish Wolfhound with the size of a Great Dane.
They usually weigh between 100 and 200 pounds. Their serene disposition makes them great pets for those who live in apartments or small houses.
Some common health problems include hip dysplasia and bloat.
17. The Greyhound x Great Dane Mix
The Greyhound Dane is an active and elegant breed that blends the speed of a Greyhound with the size of a Great Dane.
These dogs weigh anywhere from 65 to 170 pounds and need lots of daily exercise. If you wonder if your mixed breed is happy, you can take a look at this article about 17 adorable signs that your dog is happy and loves you.
Bloat and joint issues are among their most frequent health concerns.
18. The American Foxhound x Great Dane Mix
When you cross an American Foxhound with a Great Dane, you get a pup that combines agility and size – just like its Great Dane parent!
The Foxy Dane inherits hunting skills from its hound side while maintaining those majestic proportions that make Danes stand out among other breeds.
These hybrids are usually energetic dogs and tend to be quite friendly towards virtually everyone and everything around them, including children and pets alike, whether strangers or not.
But then again, any dog should never be left unsupervised with kids because anything can happen at anytime!
Typical health problems may include hip dysplasia or ear infections; hence, regular exercise and fulfilling their nutritional needs are key factors in keeping these breeds of dogs fit and healthy.
19. The Anatolian Shepherd x Great Dane Mix
Combining the protective instincts of the Anatolian Shepherd with the imposing presence of the Great Dane, this mix results in a vigilant and gentle dog.
They serve well as family protectors and farm guards due to strong protective instincts inherited from one parent while having an imposing appearance thanks to the other.
They can be trusted around children, provided they have early socialization done.
However, it is worth noting that these good dogs tend to be quite reserved towards strangers, so early exposure becomes paramount in ensuring good behavior later on in life.
Joint problems often arise among them alongside bloating, so it’s important to monitor their diet and ensure they get plenty of exercise.
20. The Corgi x Great Dane Mix
The result of crossing a Corgi with a Great Dane usually leads us to get a medium-sized or large-sized dog that is robustly built.
The Corgi Great Dane mix tends to be affectionate plus intelligent, showing lots of playfulness inherited from one side (Corgis) while being quite friendly towards people around them, including unknown visitors, due to another parent’s genes (Great Danes).
They make great pets for families because they have outgoing characters and love making new friends.
However, back issues may arise, similar to those seen in Corgis. Hip dysplasia has also been found to be common among these crosses.
Therefore, regular vet checkups and maintaining a healthy weight become must-do activities.
21. The Beagle x Great Dane Mix
Beagle Great Dane mixes are always interesting since each brings unique qualities courtesy of their genes!
In most cases, this hybrid tends to become curious and energetic, just like its smaller parent behaves.
These mixes are friendly dogs, too, which means they can get along with kids easily and other animals if socialized properly during early stages.
Another characteristic associated with them is a good sense of smell, as they tend to follow scents sometimes.
Due to their beagle-like ears, ear infections may affect them, while joint problems could also arise.
22. The Chihuahua x Great Dane Mix
The Chihuahua Great Dane mix is a unique and often surprising combination.
Generally, this crossbreed leads to a dog that is small or medium-sized, and it inherits features from both its parents.
These breeds are energetic and loving; they usually create strong relationships with their owners.
Dental problems and joint disorders could be among the many health issues resulting from the size difference between these two dogs.
Therefore, it is essential to provide them with proper dental care, such as regular teeth brushing or cleaning by a vet, as well as a balanced diet necessary for this mix.
23. The Chow Chow x Great Dane Mix
A Chow Chow Great Dane mix results in a dog that combines the independent and sometimes aloof nature of the Chow Chow with the gentle and friendly demeanor of the Great Dane.
Typically, these dogs are loyal and protective of their families.
This hybrid requires consistent training and regular socialization since it can turn out stubborn if not correctly trained early enough while young.
Just like any other pet, regular veterinary care should be provided for monitoring purposes given some health concerns, including hip dysplasia, which may affect them due to their large size.
To Sum It All Up
Each of these mixed breed pups has something special about themself.
Great Danes mixed with other breeds can have many large differences in temperaments, sizes, and traits that will fit into various homes or lifestyles.
For a better idea of how big Great Danes get, read through this Great Dane growth chart, which contains all the important information.
They take all the best traits from both parent breeds, thus producing various lovely companions we mentioned today.
Whether one needs an active protector or an extremely loving friend, an appropriate Great Dane mix exists for anyone’s liking.
Nandina has been a lifelong dog owner and enthusiast. She shared her home with multiple breeds, including Giant Schnauzers, Cane Corsos, and Huskies. Currently, she is raising a three-year-old rescue and a working-line German Shepherd puppy.
Actively engaged in IGP dog sports for two years, Nandina is a certified instructor for basic obedience and socialization. She works as a trainer in her local dog sports club, and in her spare time, she handicrafts biothane gear for dogs.